WebKen J. Ishii, Shizuo Akira, in Clinical Immunology (Third Edition), 2008 TLR1, 2, 6, AND 10. TLR2 is a major mammalian TLR that can recognize lipoproteins derived from bacteria, viruses, fungi, and parasites. It acts by forming heterodimers with either TLR1 or TLR6. 10–12 The molecular tree of the TLR family indicates that specific recognition of … WebOct 14, 2024 · Significance. To ensure immunity, and yet limit pathology, inflammatory responses must be confined within the proverbial “Goldilocks zone.”. TLR4 is the …
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