Topbp1 rad51
Web11. nov 2024 · h, Quantification of CIP2A and HA-TOPBP1 mitotic IRIF in DLD1 cells expressing variants of sgRNA-resistant TOPBP1 (TOPBP1*) or EV encoding only the HA … WebMechanistically, TOPBP1 physically binds PLK1 and promotes PLK1 kinase–mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin. Overall, our results provide mechanistic insights into TOPBP1’s role in HR, with potential clinical implications for cancer treatment.
Topbp1 rad51
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Web7. feb 2011 · It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. Class Genetic Information Processing; Replication and repair BRITE hierarchy Pathway map WebTOPBP1 gene product. Dpb11, KIAA0259, TOP2BP1 . This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction …
Web10. jan 2024 · a Western blot analysis of TopBP1, RAD51, and GAPDH levels in HFK-, HFK-31-, and HPV31-positive CIN612 cells differentiated in high-calcium media for the … WebThese findings confirm that TOPBP1 and MRE11, upstream components of the ATR pathway, are required for viability of PARP14-deficient cells. ... View in full-text Context 7 ... H3 phosphorylation...
Web26. feb 2024 · TOP1 (transient breaking and rejoining of single-stranded DNA): Topoisomerase I; SRSF2 (RNA-binding protein): serine and arginine rich splicing factor 2; U2AF1 (splicing factor): U2 small nuclear RNA auxiliary factor 1; SETX (helicase): Senataxin; XRN2 (DNA incision): 5′-3′ exoribonuclease 2; DHX9 (helicase): DEAD box helicase 9; … Web22. máj 2024 · Here, we report that TOPBP1 interacts with the RNA-binding protein HTATSF1 in a cell-cycle- and phosphorylation-dependent manner. Mechanistically, CK2 …
Web21. mar 2024 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Seckel Syndrome . …
Web31. aug 2024 · Mechanistically, CIP2A was discovered genome-widely the closest functional homologue for DNA-damage proteins TopBP1, RHNO, POLQ, NBN and PARP1. CIP2A … picatinny rail mounted rangefinderWebThese panels are a focused compilation of genes based on their role in a biological process, disease, or pathway. Targets represent a diverse set of signaling molecules as well as upstream and downstream effectors. Panels were modeled after SAB PCR arrays and utilize PrimePCR expertly designed and experimentally validated assays. top 10 co op games pcWeb1. máj 2024 · TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome … picatinny rail mount for glock 19Web1. feb 2016 · Mechanistically, TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 … National Center for Biotechnology Information picatinny rail mounted bipod adapterWeb15. aug 2024 · A direct interaction between CIP2A and a DNA repair scaffold protein TopBP1 was identified, and CIP2A inhibition resulted in enhanced DNA damage-induced TopBP1 … top 10 copper minersWeb25. jan 2016 · Because RAD51 phosphorylation at serine 14 and threonine 13 facilitates RAD51 recruitment to IR-induced damage sites (Yata et al., 2012), absence of RAD51 … top 10 cool pillowsWeb21. júl 2024 · TOPBP1 loading RPA-RAD51 exchange Introduction Homologous recombination (HR) is a high-fidelity pathway in repairing of DNA double-strand breaks … picatinny rail mounted mag holder